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APAP toxicity could be due to the ingestion of a single overdose or too frequent doses with therapeutic intent ( It has been documented that PA administration provided protection through metal chelation and its antioxidant properties ( The present data based on APAP-induced hepatotoxicity in mice identified that PA treatment for 7 days at a dose of 200 mg/kg/day has critical actions in modulating APAP-induced liver toxicity in mice

P21 is BBB permeable with a plasma half-life exceeding six hours, giving it sustained access to brain tissue

Aneurysm wall enhancement in unruptured intracranial aneurysms: A histopathological evaluation