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Description

Scientific Background

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It has been shown that knockdown of the GLS-1 gene in acute myeloid leukemia (AML) cell lines disrupted glutamine-driven OXPHOS, resulting in reduced cell proliferation and the induction of apoptosis (10)

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10.3390/biom7020038 Biomolecules 135 LoquetA.SgourakisN

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For instance, SIRT7 has been identified as a key player in the pathogenesis of immune-mediated intestinal inflammation, specifically in inflammatory bowel disease (IBD)

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