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We hypothesize that the failure of intrinsic-solubility approaches arises from inaccuracies in the predicted valuesalthough Starling is a state-of-the-art p K a -prediction model, it still routinely predicts values that are wrong by 0.51.0 p K a unit, which can correspond to a 10x difference in the predicted value

doi:10.1073/pnas.2436556100 Smriga M, Ando T, Akutsu M, Furukawa Y, Miwa K, Morinaga Y

Int J Mol Sci 23(11):6046 E S, Srikanth MS, Shreyas A, Desai S, Mehdi S, Gangadharappa HV, et al

Its tolerance to 10% NaCl and quaternary ammonium disinfectants enhances its persistence in healthcare settings (Ahmad and Alfouzan, 2021) ( Supplementary File 1 )