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In much of the literature, TB-500 refers specifically to the ~17-amino-acid fragment containing the LKKTETQ actin-binding motif the minimal sequence responsible for T4s cytoskeletal activity

Moreover, it was postulated that the aromatic ring of the 3-homotyrosine side chain and the C-terminal phenyl ring interact and Phe550 in IRAP further stabilizes aromatic/hydrophobic packing ( More recently, a crystal structure of IRAP with the macrocyclic peptide inhibitor 23 (HA08) was reported (Mpakali et al., 2020)

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