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Its levels drop dramatically when the toxic load is large Detoxifies many xenobiotics Chelator of lead, mercury, cadmium, and arsenic Prevents neuropathy from chemotherapy Maintains reduced state of other antioxidants: vitamin C & E Supports numerous metabolic and biochemical reactions: DNA synthesis and repair Protein synthesis Prostaglandin synthesis Amino acid transportation Enzyme activation Glutathione is a powerful antioxidant made in the bodys cells, using amino acids: glutamine, glycine, and cysteine

The polyubiquitin chain, which is essential for degradation of most substrates by the 26S proteasome, is formed through isopeptide bonds between the carboxyl terminus of Gly76 of one ubiquitin and the amino group of the lysine residues at positions 48 (K48) of another ubiquitin molecule (Chau et al., 2007) and mice (Irmler et al., 2002