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While systemic absorption is minimal, topical delivery ensures the concentration is highest at the site of concern (pigmentation, dark spots), leading to excellent localized brightening effects

Further, cyanocobalamin and hydroxocobalamin are available by prescription in an injectable form to treat pernicious anemia, and cyanocobalamin is available as a prescription nasal spray

Shifting T cell metabolism from a hyper-glycolytic state toward OXPHOS and FAO represents a promising approach to restore immune homeostasis

It needs to be emphasized that this strategy should be applicable to any cell surface protein of sorting pathway, regardless of physiological activity of targeting proteins