de la Torre BG, Albericio F (2023) The pharmaceutical industry in 2022: an analysis of FDA drug approvals from the perspective of molecules
This conversion can be initiated by plant-derived myrosinase, released upon tissue damage (e.g., chewing), or by microbial myrosinase in the gut ( The pharmacokinetic profile of SFN is characterized by rapid absorption, with peak plasma concentrations of SFN and its metabolites occurring within 13 hours post-consumption, and a relatively short elimination half-life ( 3.2 The gut microbiome: a metabolic gatekeeper A pivotal, and often rate-limiting, step in SFN activation is the hydrolysis of glucoraphanin by the gut microbiota
[DOI] [PMC free article] [PubMed] [Google Scholar] Kongmalai T, Srinonprasert V, Anothaisintawee T, Kongmalai P, McKay G, Attia J, et al
receives research funding from GSK