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(8) Furthermore, FOXO4's role in the IIS pathway suggests it might modulate the actions of diet and environmental factors on cell aging, acting as a mediator between external factors and cellular longevity pathways

I recommend removing triggering foods from your diet if you have Hashimotos, regardless of if you are doing the Liver Support Protocol, because this results in symptom improvement for many people, and for some theyre even the root cause of their Hashimotos

Mechanistic studies could be expanded to elucidate the pharmacological mechanisms of TCM and TM formulas and medicines in the context of HACE