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In vivo suppression of major histocompatibility complex class II expression on porcine vascular endothelial cells by an HMG-CoA reductase inhibitor

Although several studies have documented that SUN induces its cardiotoxicity by inhibiting AMPK and altering energy status in mitochondria, the effects of SUN on AMPK downstream signal and the role of substrate utilization are not studied to date

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It activates the Nrf2 pathway and upregulates detoxification enzymes, such as glutathione S-transferase