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The direct use of protein neurotrophic factors such as HGF as therapeutic agents has two serious limitations: 1) large size and hydrophilic character precludes BBB permeability

In the UK, standard maintenance therapy for pernicious anaemia is typically hydroxocobalamin 1mg by intramuscular injection every three months (or every two months if neurological symptoms are present), as per BNF and NICE guidance

If youre serious about reversing loose skin, thinning skin, or even damaged skin GHK-Cu is the best place to start and you can find my full breakdown of GHK-Cu peptide benefits in the linked article

Synthesis of chitosan based reduced graphene oxide-CeO2 nanocomposites for drug delivery and antibacterial applications