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Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension

the clinical relevance of this finding in humans is unknown, and in UK and EU prescribing information this is noted as a precaution rather than a formal contraindication but individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2) should discuss this with their doctor

Each of those symptoms can occur either alone or with others

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