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Interestingly, COX-2-deficient mice are protected against induction of PD, which was not explained by reduced inflammation but by prevention of DAQ formation (202, 228, 229)

As a result, achieving meaningful systemic exposure through oral administration often requires significant formulation innovation

Mitochondrial transport and distribution correlate with synaptic activity [44]

Effect of BPC 157 on brain pathology By manually counting all red neurons, which are those that are pathologically altered due to ischemia and reperfusion injuries, as well as healthy neurons at 24 and 72 hr of reperfusion, we revealed that BPC 157treated animals had far less neuronal damage than control animals and consistently had more healthy neurons (Figures 4 and 5)