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Chronic nicotine treatment has deleterious effects on vascular functioning and catecholamine modulation, which may compromise sexual function

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One clinical laboratory study examined the effects of methoxsalen, a CYP2A6 inhibitor, on cigarette smoking and found that methoxsalen in combination with oral nicotine decreases carbon monoxide exposure, smoking rate, latency between lighting the first and second cigarettes, and number of puffs taken (Sellars et al., 2000) compared to a placebo-placebo condition