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Cytoplasmic glutathione levels impact glutathione diffusion through nuclear pore complexes [55], playing a role in oxidative signaling during proliferation, epigenetic control of histone activity, and the cell cycle control, mainly in the S + G 2 /M phase [56,57]

We believe maintaining the glutathione-to-iron ratio is very important, because if you have too little glutathione, then iron becomes very reactive, and if you have too much glutathione, the iron will not be usable. Their experiments determined that SLC25A39 carries a unique iron signature on its surface as part of the glutathione sensing mechanism

10.1152/ajprenal.00489.2016 Am J Physiol Renal Physiol