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Moreover, a clinical trial with UC patients comparing the use of transdermal nicotine patches to placebo patches suggested that the direct use of nicotine is more effective in controlling mild-to-moderate colitis manifestations (57, 58)

The Centers for Disease Control and Prevention states that "the number of states that enacted statewide comprehensive smoke-free policies (i.e., no smoking allowed in workplaces, restaurants, and bars) increased sharply, from zero states in 2000 to 26 states in 2010, and almost half of U.S

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The results indicated that CSE stimulation (0.25%-1%) significantly increased the proportion of iTreg cells in a dose-dependent manner (Fig