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& Semple, J

In breast cancer, CHAC1 overexpression promotes both proliferation and migration, while in ovarian cancer, its impact is primarily restricted to cell migration, with minimal effect on proliferation (Metha et al

10.1089/rej.2008.0772 183 PietrzakD.KasperekK.RkawekP.Pitkowska-ChmielI

The C-terminal domain contributes, together with the N-terminal domain, to shaping the co-substrate binding site, which is termed H-site, from the hydrophobic nature of co-substrates