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These alterations contribute to systemic inflammation by increasing the production of pro-inflammatory cytokines, including interleukin (IL)-1, IL-6, IL-8, IL-13, tumor necrosis factor-alpha (TNF-), and transforming growth factor-beta 1 (TGF-1) [24]

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We excluded individuals with missing information as well as those with a preexisting diagnosis of myocardial infarction (MI), stroke, or end-stage kidney disease based on the 10th International Classification of Diseases (ICD-10) codes documented between January 1, 2002, and the day of the 2009 NHSP checkup for each subject to study incident outcomes