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Selank also appears to stabilize brain-derived neurotrophic factor (BDNF) levels an interesting overlap with Semax though its primary BDNF-related action is more about preventing stress-induced BDNF reduction than actively increasing it

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To perform virtual screening using pharmacophore model ensembles coupled with YN2, 5 parameters were required: the number of stable and unstable conformations, the minimum ensemble phase score value among known active molecules (, the maximum ensemble phase score value among known active molecules , and the YN2 threshold