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Plant J 4:215223 Demidchik V, Shabala S (2017) Mechanisms of cytosolic calcium elevation in plants: the role of ion channels, calcium extrusion systems and NADPH oxidase-mediated ROS-Ca 2+ hub

(1998) characterized the compounds as Ang IV receptor agonists and some of them, e.g., 8 with the straight four-carbon chain of the Nle residue at position one, exhibited very high affinity to the binding site (IC50 values 30-fold higher affinity (Ki = 1.7 nM) than Ang IV and improved both selectivity and metabolic stability (Lukaszuk et al., 2008

other components cleared more rapidly The relationship between rapid plasma clearance and prolonged biological effects represents a key area requiring further mechanistic investigation across all four components and their potential interactions

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