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In our study, we observed the senescence of RPE cells despite the concomitant induction of autophagy following GSH depletion

Cagrilintide is a long-acting analog of the pancreatic hormone amylin, developed by Novo Nordisk through fatty acid acylation to enable once-weekly subcutaneous dosing

Studies have shown that oxidative stress upregulates the expression of intercellular adhesion molecule 1(ICAM-1) in epithelial cells through an IL-6/AKT/ST4T3/NF-KB dependent pathway, and its upregulation is closely related to pro-inflammatory cytokines such as IL-6, IL-1, and TNF- (44)