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THE GH, IGF-1, AND INSULIN INTERPLAY IN TYPE 1 DIABETES MELLITUS THE GH, IGF-1, AND INSULIN INTERPLAY IN TYPE 2 DIABETES MELLITUS AND OBESITY THE GH, IGF-1, AND INSULIN INTERPLAY IN LIVER FAILURE THE GH, IGF-1, AND INSULIN INTERPLAY IN ACROMEGALY CONCLUSIONS Article information References ABSTRACT This review intends to provide the reader with a practical overview of several (patho)physiological conditions in which knowledge of the interplay between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and insulin is important

Replacing the sulfonic acid at position R 1 with a sulfonamide group ( 33 ) resulted in a drastic decrease in solubility of the fragment with a concomitant reduction of binding to TRF1 TRFH by CPMG, whilst the dimethyl sulfonamide 35 or the even bigger benzyl sulfonamide 36 showed an even poorer solubility and a loss of TRF1 TRFH binding (Table 1)

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