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111 Infliximab (IFX) was the first TNFi for RA treatment and consists of a recombinant chimeric monoclonal antibody composed of a human antibody backbone with a mouse idiotype

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Specific binding of the TCR to its peptide-MHC complex (S 20 FLLTRILTI_HLA-A*02:01) was dose-dependent with a half-maximum binding activity of 2.1 nM (Fig