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[3][4] Research has examined T4 (and its TB-500 fragment) in the context of: Cell migration at wound margins Corneal and dermal wound healing in preclinical models [5] Cardiac repair following ischemic injury an area of active investigation Hair follicle stem cell migration Anti-inflammatory modulation The active 17-amino-acid sequence is well-characterized, and synthetic TB-500 is widely used in research as a stable proxy for full-length T4 protein

Weinberg, Hallmarks of cancer: the next generation, Cell , vol

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The mechanism of action, involving natural beta-3 adrenergic receptors and lipolytic pathways, suggests that chronic use is unlikely to produce novel safety concerns beyond what was observed in clinical trials