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Read the full study: Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism (Am J Physiol Endocrinol Metab 2000)

(Nature, 2014) used an antisense oligonucleotide to knock down NNMT in mice and reported reduced fat-mass gain, better glucose tolerance, and lower liver triglycerides the founding paper for the whole NNMT-inhibitor field