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464 In addition, topical rapamycin treatment reduces the levels of aging markers in aged skin tissue and improves skin health (NCT03103893)

Several reasons mediate the therapeutic potential of temozolomide, including glioma stem cells, O-6-methylguanine-DNA methyltransferase (MGMT) mutations, DNA repair mechanisms, protein kinase B (Akt) pathway, Wnt/-Catenin pathway, Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, autophagy, epigenetic modifications etc., as discussed elsewhere [206]