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Pregnancy and breastfeeding increase B12 requirements, and pregnant women with B12 deficiency may need more frequent monitoring and potentially adjusted treatment schedules

Human growth hormone, or HGH, is released by the pituitary gland to promote height in puberty, muscle growth, and bone strength (3)

In accordance with this, it has been estimated that the steady-state concentration of superoxide in the mitochondrial matrix is 5- to 10- fold higher than in the cytosol ( Although ROS generated under physiological conditions are not harmful, and likely play a signaling role, toxic or pathological conditions that lead to an impairment of mitochondrial function can increase the release of ROS

In rare cases, especially with high doses or improper administration, more serious side effects can occur, such as issues affecting the liver or kidneys