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2023;46(Suppl 1):S15890

Despite the use of fungal CYP51A1 inhibitors in preclinical models, their applicability to human diseases is limited due to structural differences between human and microbial CYP51A1

Such mechanism was first described in the studies of Hogestatt et al

When to absolutely discard expired medication Certain situations demand immediate disposal regardless of how close to or past the BUD: Any visible cloudiness, particles, or color change Vial was frozen at any point Extended exposure to temperatures above 30C (86F) More than 21 cumulative days at room temperature Unusual smell from the vial More than 7 days past the assigned BUD For comparison, the same principles apply to using expired semaglutide and other compounded GLP-1 medications