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Choi et al., 2016, reported that piceatannol (a resveratrol metabolite found in red wine) affected HDAC expression in a mouse model and concluded that it may be a valuable therapeutic agent in renal fibrosis by decreasing HDAC4 and HDAC5 protein expression [264]

If the solution was clear and became cloudy during storage, discard it this indicates microbial growth and the solution is no longer suitable for research use

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Furthermore, understanding how different formulations modulate astaxanthins bioavailability and tissue distribution will be critical to fully translate its mechanistic potential into consistent clinical benefits