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Glutamate plays a critical role in neuronal migration and plasticity by being an excitatory neurotransmitter, and an excess of glutamate is expected to result in the excitotoxicity-induced apoptosis of neurons

Much of the support comes from case series, retrospective studies, and physician experience

It was found that SLC7A11- and ferroptosis-related gene signatures (lipid metabolism-associated genes: ACSL4, ALOX5, ACACA, ZEB1, FADS2 and antioxidant metabolism-associated genes: NOX1, GCLM) offer prognostic value in bladder cancer and that targeting these genes is therapeutically beneficial (108)

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