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When the concentration of Ca 2+ in the cytoplasm reaches a certain level, the calcium storage pool in the endoplasmic reticulum also releases Ca 2+ , inducing ERS ( 2+ , increasing the permeability of the endoplasmic reticulum membrane by promoting redox modification of Ca 2+ channels, leading to the release of Ca 2+ reserves from the endoplasmic reticulum into the cytoplasm and inducing Ca 2+ overload ( 2+ overload regulates NADPH oxidase (NOX) and the electron transport chain (ETC) in mitochondria to promote ROS production (92)

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176,177,178 Notably, in individuals of European ancestry, the genetic control of SLC2A9a and SLC2A9b isoforms, situated at basolateral and apical membranes respectively, constitutes a prominent genetic signal

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