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Trials of combination NRT were used to inform this estimate because: (1) randomized trials of a high-dose nicotine patch are not available to inform the projected treatment size, and (2) similar to nicotine patch, combination NRT also allows upward titration to reach satiety

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In local budgets, "there is no spare money lying around to do extra duties." Funds for Enforcement As part of the Tobacco and Vapes Act, the UK government allotted 10 million ($13.2 million) to hire about 80 new enforcement officers in England, with the goal of cracking down on underage sales and illegal tobacco and vapes