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The multi-system nature of fibromyalgia, affecting sleep architecture, pain processing, immune function, and cognitive performance simultaneously, demands interventions capable of addressing multiple pathways rather than single targets

This mechanism is relevant to neuropathy because NF-kB-driven inflammation is a central mediator of nerve damage in diabetic neuropathy, autoimmune neuropathies, and chemotherapy-induced peripheral neuropathy

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54 Via a peripheral mechanism, this is thought to contribute to lower insulin sensitivity and the development of insulin resistance