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For example, the variant 677T is most commonly associated with cerebral vascular accident (stroke), elevated homocysteine, cardiovascular disease risk, peripheral neuropathy, deep vein thrombosis, early-onset heart disease, stillbirth, neuro-tube defect, cleft lip, and preeclampsia

This work was supported by the Zhuhai Science and Technology Innovation Bureau (No.2320004000290 and No.2420004000022)

Abnormal folate metabolism has been identified in patients with ASD

Taken together, these results support a model in which metformin suppresses TXNIP expression not through AMPK activation, but via mitochondrial complex I inhibition, leading to increased NADPH production, enhanced antioxidant gene expression and ROS reduction