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Targeting p53 presents a substantial risk of off-target effects

Small size fullerenol nanoparticles suppress lung metastasis of breast cancer cell by disrupting actin dynamics

doi: 10.1038/s12276-023-01020-1, 141 YamagataK

In fact, apart from ensuring direct access through the mucin, it was this recognition (of such a low 2-3uM solubility for niclosamide at neutral pH), that went into the initial thinking (see Supplemental Information S1 ) and prompted the invention and development of a niclosamide solution as opposed to any microparticle formulation that were all explored in the series of provisional patents (48)