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Rational targeting of GPX1, GPX4 and TXNRD1 holds high therapeutic potential in different pathological settings, where lipid peroxidation is either harmful or can be triggered for therapeutic purpose, as it is the case in numerous cancers and more particularly AML
Summary: True vitamin B12 overdose is exceptionally rare because it is water-soluble and excess amounts are excreted through urine rather than accumulating in body tissues
The docket closes on July 22, 2026, and comments submitted after July 9 but before the docket closes will still be taken into consideration by FDA
Slower escalation reduces the risk of severe nausea and dehydration, which can be more dangerous in older adults with reduced physiological reserves
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