10.1021/ac980059c 263 Hoaglund-HyzerC
Dhaliwal, MD, board-certified in Diabetes, Endocrinology, and Metabolism, Springfield, VA
In fact, glutathione is present in lung tissue at concentrations about 140 times higher than serum , which helps explain why researchers have focused on local respiratory delivery rather than relying only on systemic routes like oral or IV use, as noted in the ClinicalTrials.gov record for the inhaled glutathione cystic fibrosis trial
Many drugs look promising in cells, mice, or tissue samples but fail in later stages because: The treatment doesnt work well enough in humans It causes side effects at real doses The effect fades over time The human joint environment is much more complex than the lab So while we are hopeful, there is a long road ahead before this approach could become a real treatment