In Vitro 20 , 1837 (2006)
According to our knowledge, there are not such precise investigations with stable isotopes conducted for the other B-vitamins, however a cross-sectional study in age matched (non-supplement users) pregnant, lactating and non-pregnant women with B-vitamin intake within the recommended levels, did not find significant differences among the three groups of women in the 24-hour urinary excretion of vitamin B 6 , riboflavin and vitamin B 12 (Reference Shibata, Fukuwatari and Sasaki33)
Mechanistically, an expanding body of preclinical/translational research suggests that the gut-microbiome impacts breast carcinogenesis and therapy through several interrelated pathways-chiefly in terms of its estrobolome (microbial pool of genes dedicated to estrogen metabolism), bioactive microbial metabolite synthesis, systemic/mucosal immunity modulation (influencing T-cell subsets/myeloid cell function/inflammatory cytokine networks) also together with drug pharmacokinetics/pharmacodynamics (175)
Allegaert K, de Hoon J, Verbesselt R et al , Intra- and interindividual variability of glucuronidation of paracetamol during repeated administration of propacetamol in neonates
