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These processes not only compromise cellular bioenergetics but also trigger immune responses through sensors such as cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING), or activate NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasomes, leading to secretion of proinflammatory cytokines such as interleukin (IL)-1 (Mills et al., 2017)

Febuxostat is generally only prescribed for patients who do not tolerate allopurinol

Dopaminergic activity increases in ways that enhance motivation, focus, and reward processing without the dysregulation associated with stimulant drugs

Electrophysiology recordings Before sacrifice, the animals from the 30-, 90-, 180-, and 360-day postspinal cord injury interval groups were placed in a wooden box with their tails exposed