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As the level of LP end products is solely dependent on the availability and proximity of the PUFAs, 149 it is logical to assume that disbalance of key PUFAs (as measured by peroxidation index, calculated for a known PUFA tissue composition 211 ) could contribute to interindividual differences

4.5 Regulation of skin and gut microbial homeostasis In AD, the disruption of skin and gut microbial homeostasis is increasingly recognized as a critical factor contributing to the initiation and persistence of chronic inflammation and epithelial barrier dysfunction (Pessa et al., 2023