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On the other hand, ferroptosis can directly impair the antitumor immune response by negatively affecting key immune cells, including natural killer (NK) cells, B cells, cytotoxic T cells, and antigen-presenting cells (APCs), which are critical components of antitumor immune defense

131 The production of RONS increases the sensitivity of cells to genotoxic drugs by decreasing the activity of DNA-PKcs, hindering repair processes, and leading to the accumulation of DSBs

You may feel a slight pull as you insert the needle, which is a good sign the vials seal is intact