This reduces the amount of empty space in the box, which in turn reduces shipping costs

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Experts at the Center for Tobacco Studies at Rutgers were part of a National Academies of Sciences, Engineering and Medicine committee commissioned by the Food and Drug Administration and the National Institutes of Health to address these questions
Open J Clin Diagn 3:58 Gorska KR, Domagala-Kulawik J, Korcznski P, Nejman-Gryz P, Kosciuch J, Hildebrand K, Chazan R (2008) Comparison of cellular and bichemical markers of airway inflammation in patients with mild -to-moderate asthma and chronic obstructive pulmonary disease: an induced sputum and bronchoalveolar lavage fluid study