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10.1016/j.ebiom.2021.103290 239 XuY.HuangX.HuangfuB.HuY.XuJ.GaoR.et al (2023)

Skin type: Oily skin tolerates topical GHK-Cu well

Methods In this phase 3a, double-blind, randomized, placebo-controlled trial conducted in 12 countries, we assigned adults with a body-mass index of 27 or more, a glycated hemoglobin level of 7 to 10%, and type 2 diabetes in a 3:1 ratio to receive once-weekly cagrilintide-semaglutide (2.4 mg each) or placebo, along with lifestyle intervention, for 68 weeks

These compounds include gallic acid, 3,4-dihydroxyphenylacetic acid, 4-hydroxybenzoic acid, p-coumaric acid, vanillic acid, ferulic acid, (-)-epicatechin, neochlorogenic acid, procyanidins, proanthocyanidins B1 and B2, an A-type trimer, scopoletin, and (E)-chlorogenic acid (also known as caffeylquinic acid, caffetannic acid, helianthic acid, and igasuric acid) (458)