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More recent evidence revealed an endothelial-cell-instigated Notch-mediated pathway in perivascular sub-lining synovial fibroblasts, that establishes a positional gradient for sub-lining synovial fibroblasts differentiating to lining synovial fibroblasts [31]

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Given the heterogeneity of NPCs, we further analyzed the scRNA-seq data (GSE165722) 26 from human NP tissues with mild (grades II and III) and severe (grades IV and V) degeneration to identify the potential pathogenic factors associated with IDD

Patients with chronic fatigue syndrome have reduced absolute cortical blood flow