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Neurogenesis (preclinical): Animal work links TREK-1 blockade to increased hippocampal neurogenesis and synaptogenesis markers [3]

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At the heart of these processes are the NF-B and MAPK signaling pathways, which control the transcription of pro-inflammatory mediators including COX-2, CRP, LOX-2 and cytokines IL-1, IL-6, IL-8 and TNF- (9799)