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A valid-PRS established based on such a process thus fulfils the definition of an instrumental variable mentioned above if it remains associated with the designated phenotype of interest

Classical culture systems with human small airway cells are unable to reproduce the breathing motions of the lung and commonly used laboratory animals cannot reflect human smoking because they breathe through their noses, and their inflammatory responses differ from those in humans

Unlike larger vaping devices that can produce substantial vapour clouds, cigarette-like e-cigarettes typically generate modest amounts of vapour, making them suitable for use in various social and professional settings where discretion is valued

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