Hepatotoxicity Several oral agents, especially tyrosine kinase inhibitors (TKIs) such as pazopanib, lapatinib, and sunitinib , are associated with hepatotoxicity , which can range from mild transaminase elevation to fulminant hepatic failure
Discussion We have attempted to illustrate likely risks associated with major surgery and extended possi- ble analgesic use in patients [2] including poor initial healing, lesions occurring in other organs during the most critical early period, COX-blockade, and additional NOS-blockade, in a rat model permitting acute evaluation within 24 hours
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