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These results fit within the broadening body of information in support of important roles for the microbiotagutbrain axis and inflammation in MDD pathophysiology

Preclinical studies conducted on rats showed that the administration of caffeine in doses of 30 mg/kg/day and 100 mg/kg/day has beneficial effects on oxidative stress leading to a decrease in MDA values (in a dose-dependent manner) and advanced oxidation protein products (AOPP)