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Biomolecules 13 , 17681790, (2023)

In organotypic hippocampal slice cultures, Dihexa and Nle-AngIV similarly augmented spinogenesis, with control slices showing 7 spines per 50-m dendrite length, compared to 11 for both Dihexa and Nle-AngIV treated slices [1]

Although there are theoretical concerns about the possibility of hypoxemia with voxelotor therapy, cardiopulmonary exercise tests in 12 patients in the phase 1/2 GBT440-001 investigation who received voxelotor for 90 days showed no significant differences from baseline compared to the control

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