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It is worth noting that this research is longstanding, with some of the earliest studies dating back to 1998

doi:10.1136/bjophthalmol-2011-300539

Additionally, ATF3 regulates genes such as acyl-CoA synthetase long chain family member 4 and lipoxygenases, essential for producing and incorporating PUFAs into cellular membranes, which is a critical step in lipid peroxidation (119121)