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Overall, the literature suggests that curcumin exerts its beneficial effects through modulation of various signaling pathways, including NF-B, NLRP3, AKAP150/PKA/PP2B, miR-146a-5p/ERK, BDNF/Trkin, ROS-ERK1/2, GABAA receptor, gut-brain axis and Keap1-Nrf2-ARE, in different disease models and conditions

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Oridonin and its derivates seem to induce apoptosis through a wide range of signaling pathways, which include p38, Jnk, Erk, ROS and FasL (Ding et al., 2016

also influences melatonin and has been shown to improve sleep quality.(40) Lecithin - phospholipid found in egg yolk that supplies choline that in turn forms acetylcholine brain chemical while optimizing brain cell healthy structure.(41) Lemon Balm - traditional herb that regulates brain chemicals and their receptors to promote calmness and induce sleep.(42) Lions Mane Mushroom raises nerve growth factor to help with brain plasticity, regeneration and repair